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Mechanistic Aspects of the Palladium‐Catalyzed Suzuki‐Miyaura Cross‐Coupling Reaction
Author(s) -
D'Alterio Massimo C.,
CasalsCruañas Èric,
Tzouras Nikolaos V.,
Talarico Giovanni,
Nolan Steven P.,
Poater Albert
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202101880
Subject(s) - coupling reaction , chemistry , catalysis , competition (biology) , palladium , mechanism (biology) , reaction mechanism , biochemical engineering , combinatorial chemistry , organic chemistry , philosophy , epistemology , biology , ecology , engineering
Abstract The story of C−C bond formation includes several reactions, and surely Suzuki‐Miyaura is among the most outstanding ones. Herein, a brief historical overview of insights regarding the reaction mechanism is provided. In particular, the formation of the catalytically active species is probably the main concern, thus the preactivation is in competition with, or even assumes the role of the rate determining step (rds) of the overall reaction. Computational chemistry is key in identifying the rds and thus leading to milder conditions on an experimental level by means of predictive catalysis.