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Front Cover: Synthesis of Difluoroglycine Derivatives from Amines, Difluorocarbene, and CO 2 : Computational Design, Scope, and Applications (Chem. Eur. J. 39/2021)
Author(s) -
Hayashi Hiroki,
Takano Hideaki,
Katsuyama Hitomi,
Harabuchi Yu,
Maeda Satoshi,
Mita Tsuyoshi
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202101792
Subject(s) - difluorocarbene , front cover , scope (computer science) , chemistry , cover (algebra) , reactivity (psychology) , combinatorial chemistry , medicinal chemistry , computer science , engineering , programming language , mechanical engineering , medicine , alternative medicine , pathology
An Artificial Force Induced Reaction (AFIR) on a super computer has led to a new three‐component reaction (3CR) of amines, difluorocarbene, and the inexpensive and non‐toxic C1 source CO 2 . This reaction produces a broad range of α,α‐difluoroglycine derivatives that are bioisosteres of natural glycine. The versatility of these products is very broad; i.e., they can be used as new difluorocarbene sources, substrates for radical substitution reactions, and precursors for new NHC ligands. More information can be found in the Full Paper by S. Maeda, T. Mita et al. (DOI: 10.1002/chem.202100812).