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Front Cover: Hydrogel‐Stiffening and Non‐Cell Adhesive Properties of Amphiphilic Peptides with Central Alkylene Chains (Chem. Eur. J. 36/2021)
Author(s) -
Yaguchi Atsuya,
Hiramatsu Hirotsugu,
Ishida Atsuya,
Oshikawa Mio,
Ajioka Itsuki,
Muraoka Takahiro
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202101745
Subject(s) - amphiphile , self healing hydrogels , peptide , adhesive , hydrogen bond , front cover , materials science , chemistry , biophysics , combinatorial chemistry , polymer chemistry , nanotechnology , cover (algebra) , molecule , polymer , organic chemistry , biochemistry , copolymer , layer (electronics) , mechanical engineering , engineering , biology
Fiber‐forming peptides are of high interest for potential biomedical applications. This work presents the unexpected effects of central alkylene chains in peptides on their self‐assembly and biological properties. Insertion of the alkylene chain at the center of the peptide allowed for strengthening of β‐sheet hydrogen bonds, formation of hydrogels with increased stiffness, thermal responses and significant decrease in the cell adhesive property. This study offers a novel molecular design to tune mechanical and biological properties of peptide materials by conformational flexibility. More information can be found in the Full Paper by T. Muraoka et al. (DOI: 10.1002/chem.202100739).