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Cover Feature: A Cytotoxic Bis(1,2,3‐triazol‐5‐ylidene)carbazolide Gold(III) Complex Targets DNA by Partial Intercalation (Chem. Eur. J. 32/2021)
Author(s) -
Westhuizen Danielle,
Slabber Cathryn A.,
Fernandes Manuel A.,
Joubert Daniël F.,
Kleinhans George,
Westhuizen C. Johan,
Stander André,
Munro Orde Q.,
Bezuidenhout Daniela I.
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202101553
Subject(s) - intercalation (chemistry) , pincer movement , chemistry , dna , in silico , carbene , cancer cell lines , combinatorial chemistry , stereochemistry , crystallography , medicinal chemistry , cancer cell , inorganic chemistry , organic chemistry , biochemistry , gene , cancer , biology , genetics , catalysis
A challenging synthesis yields a bis(carbene) Au I ‐CNC pincer precursor complex that may be oxidized to a remarkably redox‐stable [Au III (CNC)Cl] + cation which shows significant cytotoxicity towards a breast cancer cell line. Electrophoresis, viscometry, and spectroscopic data suggest the likely mode of interaction of the compound with DNA involves partial intercalation, enabling it to potentially target both conventional and unconventional DNA species such as three‐way junctions (in silico data). More information can be found in the Full Paper by O. Q. Munro, D. I. Bezuidenhout, et al. (DOI: 10.1002/chem.202100598).