Front Cover: Transmembrane Transport of Bicarbonate Unravelled (Chem. Eur. J. 26/2021) | Zendy

MartínezCrespo Luis | Zendy; Hewitt Sarah H. | Zendy; De Simone Nicola Alessandro | Zendy; Šindelář Vladimír | Zendy; Davis Anthony P. | Zendy; Butler Stephen | Zendy; Valkenier Hennie | Zendy

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Front Cover: Transmembrane Transport of Bicarbonate Unravelled (Chem. Eur. J. 26/2021)

Author(s) -

MartínezCrespo Luis,

Hewitt Sarah H.,

De Simone Nicola Alessandro,

Šindelář Vladimír,

Davis Anthony P.,

Butler Stephen,

Valkenier Hennie

Publication year - 2021

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Reports

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.202101358

Subject(s) - bicarbonate , chemistry , front cover , transporter , transmembrane protein , biophysics , liposome , europium , combinatorial chemistry , cover (algebra) , biochemistry , organic chemistry , biology , receptor , ion , gene , mechanical engineering , engineering

The development of synthetic bicarbonate transporters is of high interest for potential therapeutic applications. This work presents a new assay to study bicarbonate transport, based on a europium complex that is encapsulated inside liposomes and reports changes in the intravesicular concentration of bicarbonate in a direct and highly sensitive way. The assay revealed that transporters can act via different mechanisms, involving actual transport of HCO 3 − anions or passive diffusion of CO 2 . More information can be found in the Full Paper by S. Butler, H. Valkenier, et al. (DOI: 10.1002/chem.202100491).

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