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Front Cover: Transmembrane Transport of Bicarbonate Unravelled (Chem. Eur. J. 26/2021)
Author(s) -
MartínezCrespo Luis,
Hewitt Sarah H.,
De Simone Nicola Alessandro,
Šindelář Vladimír,
Davis Anthony P.,
Butler Stephen,
Valkenier Hennie
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202101358
Subject(s) - bicarbonate , chemistry , front cover , transporter , transmembrane protein , biophysics , liposome , europium , combinatorial chemistry , cover (algebra) , biochemistry , organic chemistry , biology , receptor , ion , gene , mechanical engineering , engineering
The development of synthetic bicarbonate transporters is of high interest for potential therapeutic applications. This work presents a new assay to study bicarbonate transport, based on a europium complex that is encapsulated inside liposomes and reports changes in the intravesicular concentration of bicarbonate in a direct and highly sensitive way. The assay revealed that transporters can act via different mechanisms, involving actual transport of HCO 3 − anions or passive diffusion of CO 2 . More information can be found in the Full Paper by S. Butler, H. Valkenier, et al. (DOI: 10.1002/chem.202100491).