Cover Feature: Surprising Homolytic Gas Phase Co−C Bond Dissociation Energies of Organometallic Aryl‐Cobinamides Reveal Notable Non‐Bonded Intramolecular Interactions (Chem. Eur. J. 25/2021)

B 12 ‐derived phenyl‐corrins are antivitamins B 12 that resist the enzymatic cleavage of their Co−C bond. Surprisingly, as shown by ESI‐MS threshold CID, the Co−C sp2 bonds of phenyl‐corrins are weaker than Co−C sp3 bonds of analogous methyl‐corrins, contrasting the known effect of the hybridization on bond strengths. Hence, for the behavior of phenyl‐cobalamins as antivitamins B 12 , stereo‐electronic restrictions of the nucleophilic displacement are more critical than Co−C bond strengths. More information can be found in the Full Paper by B. Kräutler, P. Chen, et al. (DOI: 10.1002/chem.202004589).