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Modular Toolkit of Multifunctional Block Copoly(2‐oxazoline)s for the Synthesis of Nanoparticles
Author(s) -
Keckeis Philipp,
Zeller Enriko,
Jung Carina,
Besirske Patricia,
Kirner Felizitas,
RuizAgudo Cristina,
Schlaad Helmut,
Cölfen Helmut
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202101327
Subject(s) - alkyne , click chemistry , copolymer , macromolecule , nanoparticle , polymer , polymerization , oxazoline , cycloaddition , alkene , polymer chemistry , materials science , chemistry , combinatorial chemistry , nanotechnology , catalysis , organic chemistry , biochemistry
Post‐polymerization modification provides an elegant way to introduce chemical functionalities onto macromolecules to produce tailor‐made materials with superior properties. This concept was adapted to well‐defined block copolymers of the poly(2‐oxazoline) family and demonstrated the large potential of these macromolecules as universal toolkit for numerous applications. Triblock copolymers with separated water‐soluble, alkyne‐ and alkene‐containing segments were synthesized and orthogonally modified with various low‐molecular weight functional molecules by copper(I)‐catalyzed azide‐alkyne cycloaddition (CuAAC) and thiol‐ene (TE) click reactions, respectively. Representative toolkit polymers were used for the synthesis of gold, iron oxide and silica nanoparticles.