Premium
Nickel‐Catalyzed Thiolation of Aryl Nitriles
Author(s) -
Delcaillau Tristan,
Morandi Bill
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202101273
Subject(s) - aryl , catalysis , nickel , chemistry , combinatorial chemistry , ligand (biochemistry) , surface modification , molecule , transformation (genetics) , potassium , organic chemistry , receptor , alkyl , biochemistry , gene
A nickel‐catalyzed thiolation of aryl nitriles has been developed to access functionalized aryl thioethers. The ligand dcype (1,2‐bis(dicyclohexylphosphino)ethane) as well as the base KO t Bu (potassium tert ‐butoxide) are essential to achieve this transformation. This scalable and practical process involves both a C−C bond activation and a C−S bond formation. Furthermore, this reaction shows a high functional‐group tolerance and enables the late‐stage functionalization of important molecules.