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Indium Tribromide‐Catalysed Transfer‐Hydrogenation: Expanding the Scope of the Hydrogenation and of the Regiodivergent DH or HD Addition to Alkenes
Author(s) -
Li Luomo,
Hilt Gerhard
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202101259
Subject(s) - regioselectivity , tribromide , chemistry , transfer hydrogenation , indium , deuterium , aryl , electron transfer , catalysis , photochemistry , organic chemistry , medicinal chemistry , physics , alkyl , quantum mechanics , ruthenium
The transfer‐hydrogenation as well as the regioselective and regiodivergent addition of H−D from regiospecific deuterated dihydroaromatic compounds to a variety of 1,1‐di‐ and trisubstituted alkenes was realised with InBr 3 in dichloro(m)ethane. In comparison with the previously reported BF 3 ⋅Et 2 O‐catalysed process, electron‐deficient aryl‐substituents can be applied reliably and thereby several restrictions could be lifted, and new types of substrates could be transformed successfully in hydrodeuterogenation as well as deuterohydrogenation transfer‐hydrogenation reactions.