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Front Cover: Ruthenium‐Catalyzed Deuteration of Aromatic Carbonyl Compounds with a Catalytic Transient Directing Group (Chem. Eur. J. 38/2021)
Author(s) -
Kopf Sara,
Ye Fei,
Neumann Helfried,
Beller Matthias
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202101156
Subject(s) - ruthenium , catalysis , chemistry , amine gas treating , carbonyl group , deuterium , front cover , group (periodic table) , organic chemistry , combinatorial chemistry , medicinal chemistry , cover (algebra) , mechanical engineering , engineering , physics , quantum mechanics
In a joint endeavor , a ruthenium catalyst and a catalytic amine enable the deuteration of aromatic aldehydes and ketones using cheap and convenient D 2 O as deuterium source. The amine serves as a transient directing group, forming imines in situ and thus facilitating coordination of the ruthenium catalyst to the substrates. The practical applicability of this novel methodology is demonstrated by the successful deuteration of a range of (hetero)aromatic carbonyl compounds as well as pharmaceuticals. More information can be found in the Full Paper by H. Neumann, M. Beller, et al. (DOI: 10.1002/chem.202100468).