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Cobalt‐Catalyzed Aerobic Oxidative Cleavage of Alkyl Aldehydes: Synthesis of Ketones, Esters, Amides, and α‐Ketoamides
Author(s) -
Li Tingting,
Hammond Gerald B.,
Xu Bo
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202101035
Subject(s) - alkyl , catalysis , chemistry , cobalt , oxidative cleavage , bond cleavage , cleavage (geology) , organic chemistry , molecular oxygen , oxidative phosphorylation , aldehyde , oxygen , primary (astronomy) , biochemistry , materials science , physics , astronomy , fracture (geology) , composite material
A widely applicable approach was developed to synthesize ketones, esters, amides via the oxidative C−C bond cleavage of readily available alkyl aldehydes. Green and abundant molecular oxygen (O 2 ) was used as the oxidant, and base metals (cobalt and copper) were used as the catalysts. This strategy can be extended to the one‐pot synthesis of ketones from primary alcohols and α‐ketoamides from aldehydes.