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Effect of Topology on Photodynamic Sterilization of Porphyrinic Metal‐Organic Frameworks
Author(s) -
Liu YaoYao,
Chen LiJian,
Zhao Xu,
Yan XiuPing
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202100920
Subject(s) - porphyrin , metal organic framework , photodynamic therapy , singlet oxygen , topology (electrical circuits) , zirconium , aqueous solution , materials science , nanotechnology , photochemistry , chemistry , inorganic chemistry , oxygen , organic chemistry , mathematics , adsorption , combinatorics
Porphyrinic metal‐organic frameworks (MOFs) are promising photosensitizers due to the lack of self‐aggregation of porphyrin in aqueous solution. However, how the topology of porphyrinic MOFs affects the generation of singlet oxygen ( 1 O 2 ) is unclear. Here, the effect of the topology of porphyrinic MOFs on their photodynamic performance is reported. Four porphyrinic zirconium MOFs (MOF‐525, MOF‐545, PCN‐223 and PCN‐224 with different topologies: ftw , csq , shp and she , respectively) were selected to study the influence of topology on the photodynamic antibacterial performance. The 1 O 2 generation and the photodynamic antibacterial performance followed an decreasing order of MOF‐545>MOF‐525>PCN‐224>PCN‐223. The results reveal that the pore size, the distance between porphyrin, and the number of porphyrin per Zr 6 O 8 cluster in MOFs greatly affected 1 O 2 generation. This work provides guidance for designing new MOFs for efficient photodynamic sterilization.