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Hollow POM@MOF‐derived Porous NiMo 6 @Co 3 O 4 for Biothiol Colorimetric Detection
Author(s) -
Xu Mingqi,
Li Xiao,
Sha JingQuan,
Tong Zhibo,
Li Qian,
Liu Chang
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202100846
Subject(s) - detection limit , peroxidase , polyoxometalate , linear range , porosity , materials science , doping , nuclear chemistry , composite number , chemistry , nanotechnology , chromatography , enzyme , organic chemistry , catalysis , composite material , optoelectronics
Developing highly active and sensitive peroxidase mimics for L ‐cysteine ( L ‐Cys) colorimetric detection is very important for biotechnology and medical diagnosis. Herein, polyoxometalate‐doped porous Co 3 O 4 composite (NiMo 6 @Co 3 O 4 ) was designed and prepared for the first time. Compared with pure and commercial Co 3 O 4 , NiMo 6 @Co 3 O 4 (n) composites exhibit the enhanced peroxidase‐mimicking activities and stabilities due to the strong synergistic effect between porous Co 3 O 4 and multi‐electron NiMo 6 clusters. Moreover, the peroxidase‐mimicking activities of NiMo 6 @Co 3 O 4 (n) composites are heavily dependent on the doping mass of NiMo 6 , and the optimized NiMo 6 @Co 3 O 4 (2) exhibits the superlative peroxidase‐mimicking activity. More importantly, a sensitive L ‐Cys colorimetric detection is developed with the sensitivity of 0.023 μM −1 and the detection limit at least 0.018 μM in the linear range of 1–20 μM, which is by far the best enzyme‐mimetic performances, to the best our knowledge.