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Rhamnogalacturonan II: Chemical Synthesis of a Substructure Including α‐2,3‐Linked Kdo **
Author(s) -
Mancuso Enzo,
Romanò Cecilia,
Trattnig Nino,
Gritsch Philipp,
Kosma Paul,
Clausen Mads H.
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202100837
Subject(s) - tetrasaccharide , glycosylation , chemistry , substructure , stereochemistry , stereoselectivity , organic chemistry , biochemistry , polysaccharide , catalysis , engineering , structural engineering
The synthesis of a fully deprotected Kdo‐containing rhamnogalacturonan II pentasaccharide is described. The strategy relies on the preparation of a suitably protected homogalacturonan tetrasaccharide backbone, through a post‐glycosylation oxidation approach, and its stereoselective glycosylation with a Kdo fluoride donor.