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Catalytic Gold Chemistry: From Simple Salts to Complexes for Regioselective C−H Bond Functionalization
Author(s) -
Praveen Chandrasekar,
Dupeux Aurélien,
Michelet Véronique
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202100785
Subject(s) - chemistry , regioselectivity , catalysis , steric effects , surface modification , selectivity , combinatorial chemistry , ligand (biochemistry) , stereochemistry , organic chemistry , biochemistry , receptor
Gold coordinated to neutral phosphines (R 3 P), N ‐heterocyclic carbenes (NHCs) or anionic ligands is catalytically active in functionalizing various C−H bonds with high selectivity. The sterics/electronic nature of the studied C−H bond, oxidation state of gold and stereoelectronic capacity of the coordinated auxiliary ligand are some of the associated selectivity factors in gold‐catalyzed C−H bond functionalization reactions. Hence, in this review a comprehensive update about the action of different types of gold catalysts, from simple to sophisticated ones, on C−H bond reactions and their regiochemical outcome is disclosed. This review also highlights the catalytic applications of Au(I)‐ and Au(III)‐species in creating new opportunities for the regio‐ and site‐selective activation of challenging C−H bonds. Finally, it also intends to stress the potential applications in selective C−H bond activation associated with a variety of heterocycles recently described in the literature.