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Hypervalent‐Iodine(III)‐Mediated Tandem Oxidative Dearomatization/Aziridination of Phenolic Amines: Synthesis of Functionalized Unactivated Aziridines
Author(s) -
Cao YeXing,
Silalai Patamawadee,
Liu ChunFang,
Yu KeYin,
Bao Xu,
Zhao XianHe,
Saeeng Rungnapha,
Fan ChunAn
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202100762
Subject(s) - hypervalent molecule , tandem , chemistry , iodine , combinatorial chemistry , cascade reaction , ring (chemistry) , oxidative phosphorylation , organic chemistry , catalysis , materials science , biochemistry , composite material
A new hypervalent‐iodine(III)‐mediated tandem reaction involving oxidative dearomatization and in situ aziridination of phenolic amines is described, providing a mild and effective method for the assembly of structurally interesting and synthetically useful aziridines. Importantly, the densely functionalized aziridines resulting from this unprecedented tandem reaction offer a platform for expeditious access to architecturally diverse aza‐heterocycles through transformations initiated by selective ring‐opening of aziridines.