Photochemical Activation of Aromatic Aldehydes: Synthesis of Amides, Hydroxamic Acids and Esters | Zendy

Nikitas Nikolaos F. | Zendy; Apostolopoulou Mary K. | Zendy; Skolia Elpida | Zendy; Tsoukaki Anna | Zendy; Kokotos Christoforos G. | Zendy

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Photochemical Activation of Aromatic Aldehydes: Synthesis of Amides, Hydroxamic Acids and Esters

Author(s) -

Nikitas Nikolaos F.,

Apostolopoulou Mary K.,

Skolia Elpida,

Tsoukaki Anna,

Kokotos Christoforos G.

Publication year - 2021

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.202100655

Subject(s) - chemistry , moclobemide , organic chemistry , photocatalysis , combinatorial chemistry , photochemistry , catalysis , anxiety , psychology , psychiatry , antidepressant

A cheap, facile and metal‐free photochemical protocol for the activation of aromatic aldehydes has been developed. Utilizing thioxanthen‐9‐one as the photocatalyst and cheap household lamps as the light source, a variety of aromatic aldehydes have been activated and subsequently converted in a one‐pot reaction into amides, hydroxamic acids and esters in good to high yields. The applicability of this method was highlighted in the synthesis of Moclobemide, a drug against depression and social anxiety. Extended and detailed mechanistic studies have been conducted, in order to determine a plausible mechanism for the reaction.

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