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Cover Feature: Carbohydrate‐Derived Metal‐Chelator‐Triggered Lipids for Liposomal Drug Delivery (Chem. Eur. J. 23/2021)
Author(s) -
Holmstrøm Thomas,
Galsgaard Malle Mette,
Wu Shunliang,
Jensen Knud Jørgen,
Hatzakis Nikos S.,
Pedersen Christian Marcus
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202100496
Subject(s) - liposome , chelation , chemistry , drug delivery , biophysics , metal , fluorescence , membrane , biochemistry , combinatorial chemistry , organic chemistry , biology , physics , quantum mechanics
Stimuli‐responsive lipids based on a glucose head group could promote pore formation in the membrane of liposomes upon treatment with EDTA. Using a total internal reflection fluorescence (TIRF) microscopy setup, it was possible to monitor the release of a fluorescent dye from liposomes containing the metal chelator‐responsive lipids. The liposomes containing the lipids remained stable and able to incapsulate the cargo in the absence of EDTA. Only when introducing the metal chelating EDTA to the liposomes would they release their cargo through pores formed in their membrane. This could serve as a platform for future drug‐delivery systems. More information can be found in the Full Paper by C. M. Pedersen et al. on page 6917.