Multilevel Chirality Transfer from Amino Acid Derivatives to Circularly Polarized Luminescence‐Active Nanoparticles in Aqueous Medium

Chirality at different levels is widely observed in nature, but the clue to connect it all together, and the way chirality transfers among different levels are still obscure. Herein, a l ‐/ d ‐lysine‐based self‐assembly system was constructed, in which two‐step chirality transfer among three different levels was observed in aqueous solution. The chirality originated from the point chirality of amino acid derivatives l ‐/ d ‐PyLys hydrochloride, and was transferred to the planar conformational chirality of water‐soluble pillar[5]arene pR ‐/ pS ‐WP5. Then, with the aid of pR ‐/ pS ‐WP5, nanoparticles were formed that exhibited L‐/R‐handed circularly polarized luminescence with a dissymmetry factor of up to ±0.001, arising from pyrene chiral excimers. This multilevel chirality transfer not only provides a perspective to trace potential clues, and to pursue certain ways by which the chirality transfers, but also offers a strategy to create controllable CPL emission in aqueous media.