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Organic Nanoparticles with Persistent Luminescence for In Vivo Afterglow Imaging‐Guided Photodynamic Therapy
Author(s) -
Zheng Xiaokun,
Wu Wenbo,
Zheng Yue,
Ding Yiwen,
Xiang Yu,
Liu Bin,
Tong Aijun
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202100406
Subject(s) - afterglow , photodynamic therapy , in vivo , luminescence , materials science , persistent luminescence , preclinical imaging , fluorescence lifetime imaging microscopy , singlet oxygen , irradiation , fluorescence , optical imaging , biomedical engineering , chemistry , medicine , optics , optoelectronics , oxygen , biology , physics , astronomy , microbiology and biotechnology , gamma ray burst , organic chemistry , thermoluminescence , nuclear physics
Optical imaging‐guided photodynamic therapy (PDT), with precise localization and non‐invasive treatment of tumors, is an emerging technique with great potential for cancer therapy. However, impaired by tissue auto‐fluorescence that causes low signal‐to‐background ratio (SBR), most fluorescence imaging systems show poor sensitivity to tumors in vivo. In this study, we synthesized organic nanoparticles (ONPs) with persistent luminescence and good biocompatibility for afterglow imaging‐guided PDT. The ONPs displayed near‐infrared light emission with half‐life time at minute level, which offered high SBR and good tissue penetration for in vivo afterglow tumor imaging. Taking advantage of their abundant singlet oxygen generation by NIR laser irradiation guided to the tumor sites, the ONPs also enabled imaging‐guided PDT for efficient suppression of tumor growth in mice with minimal damage to major organs.
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