Premium
Redox‐Neutral Tetrafluoroethylation of Aryl Alkynes with 1,1,2,2‐Tetrafluoroethane Sulfonic Acid Leading to α‐Tetrafluoroethylated Acetophenones
Author(s) -
Kawamoto Takuji,
Noguchi Kohki,
Takata Ryotaro,
Sasaki Rio,
Matsubara Hiroshi,
Kamimura Akio
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202100137
Subject(s) - chemistry , redox , aryl , sulfonic acid , intermolecular force , polymer chemistry , aryl radical , medicinal chemistry , photochemistry , organic chemistry , molecule , alkyl
The redox‐neutral tetrafluoroethylation of alkynes with 1,1,2,2‐tetrafluroroethanesulfonic acid (TFESA) and azobis(isobutyronitrile) (AIBN) proceeds via the formation of vinyl tetrafluoroethanesulfonates followed by a radical tetrafluoroethylation. Experimental and theoretical results support an intermolecular reaction.