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Cover Feature: Light‐Triggered Nitric Oxide Release by a Photosensitizer to Combat Bacterial Biofilm Infections (Chem. Eur. J. 17/2021)
Author(s) -
Zhao Zhennan,
Li Huinan,
Tao Xuan,
Xie Yanxuan,
Yang Liang,
Mao ZongWan,
Xia Wei
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202100133
Subject(s) - biofilm , nitric oxide , bacteria , reactive oxygen species , photosensitizer , chemistry , pseudomonas aeruginosa , microbiology and biotechnology , cytotoxicity , oxygen , biophysics , photochemistry , biochemistry , biology , in vitro , organic chemistry , genetics
Upon light irradiation , a novel dual‐functional ruthenium compound releases nitric oxide (NO) and reactive oxygen species (ROS). NO induces Pseudomonas aeruginosa biofilm dispersal and liberates bacteria. The free‐floating bacteria are subsequently sterilized by ROS. Therefore, the compound can readily eradicate mature biofilms at low concentration, which reduces cytotoxicity to mammalian cells. More information can be found in the Full Paper by Z.‐W. Mao, W. Xia, et al. on page 5453.