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Cover Feature: Silver‐Promoted Fluorination Reactions of α‐Bromoamides (Chem. Eur. J. 19/2021)
Author(s) -
Mizuta Satoshi,
Kitamura Kanami,
Kitagawa Ayako,
Yamaguchi Tomoko,
Ishikawa Takeshi
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202100131
Subject(s) - chemoselectivity , steric effects , chemistry , nucleophilic aromatic substitution , stereospecificity , alkyl , alcohol , fluorine , nucleophile , cover (algebra) , ether , organic chemistry , combinatorial chemistry , nucleophilic substitution , catalysis , mechanical engineering , engineering
Open and shut with silver ! A silver‐promoted fluorine substitution reaction of α‐bromoamide has been recently developed. This methodology enables access to tertiary, secondary, and primary alkyl fluorides with chemoselectivity and stereospecificity by forming an aziridinone intermediate. The cover image depicts that molecules are closed, and opening like an umbrella. In addition, the reaction of α ‐bromoamide with O ‐nucleophiles including OCF 3 provided the sterically hindered alcohol, ester and ether. More information can be found in the Full Paper by S. Mizuta et al. on page 5930.