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Zirconium Catalyzed Hydroaminoalkylation for the Synthesis of α‐Arylated Amines and N‐Heterocycles
Author(s) -
Koperniku Ana,
Schafer Laurel L.
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202100014
Subject(s) - alkene , catalysis , chemistry , aryl , steric effects , zirconium , alkyl , substrate (aquarium) , amine gas treating , combinatorial chemistry , organic chemistry , oceanography , geology
The zirconium catalyzed hydroaminoalkylation of alkenes with N ‐aryl‐ and sterically demanding N ‐alkyl‐α‐arylated secondary amines by using commercially available Zr(NMe 2 ) 4 is reported. N ‐phenyl‐ and N ‐isopropylbenzylamine are used as amine substrates to establish the alkene substrate scope. Exclusively linear products are obtained in the presence of bulky vinylsilanes. Challenging α‐heteroarylated amines and functionalized alkene substrates are compatible with this easy to use catalyst, affording a new disconnection strategy for the atom‐ and step‐economic preparation of selectively substituted saturated α‐arylated heterocycles.