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Frontispiece: O 6 ‐Alkylguanine DNA Alkyltransferase Mediated Disassembly of a DNA Tetrahedron
Author(s) -
Copp William,
Wilds Christopher J.
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202086563
Subject(s) - dna , tetrahedron , chemistry , a dna , biophysics , microbiology and biotechnology , crystallography , biology , biochemistry
DNA nanostructures show promise for drug delivery with the ability to enter cells and can release cargo in response to stimuli. In this work, the authors show that a DNA tetrahedron can self‐assemble containing an alkylene cross‐link connecting the O 6 ‐atoms of adjacent 2′‐deoxyguanosines at the vertices’ three‐way junctions. These cross‐links are unhooked by the human DNA repair protein O 6 ‐alkylguanine DNA alkyltransferase leading to tetrahedron disassembly. For more details see the Communication by C. J. Wilds et al. on page 14802 ff.