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Frontispiece: Investigating Ugi/Passerini Multicomponent Reactions for the Site‐Selective Conjugation of Native Trastuzumab
Author(s) -
Sornay Charlotte,
Hessmann Steve,
Erb Stéphane,
Dovgan Igor,
Ehkirch Anthony,
Botzanowski Thomas,
Cianférani Sarah,
Wagner Alain,
Chaubet Guilhem
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202086163
Subject(s) - conjugate , isocyanide , combinatorial chemistry , aldehyde , trastuzumab , chemistry , ugi reaction , stereochemistry , organic chemistry , biology , catalysis , cancer , breast cancer , mathematical analysis , mathematics , genetics
Gemini reactions : In their Full Paper on page 13797 ff., G. Chaubet et al. have investigated the potential of Ugi and Passerini multicomponent reactions for the site‐selective conjugation of native trastuzumab. The conjugation proved to tolerate various aldehyde and isocyanide, and a plug‐and‐play approach was devised, allowing the facile generation of doubly labelled conjugates and antibody–drug conjugates.