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Frontispiece: Extracellular Matrix Proteins Involved in Alzheimer's Disease
Author(s) -
Ma Jun,
Ma Chao,
Li Jingjing,
Sun Yao,
Ye Fangfu,
Liu Kai,
Zhang Hongjie
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202085362
Subject(s) - extracellular matrix , laminin , disease , extracellular , neuroscience , senile plaques , amyloid (mycology) , alzheimer's disease , biology , microbiology and biotechnology , chemistry , medicine , pathology
Alzheimer's disease (AD) is one of the most intensively studied neurodegenerative diseases. Emerging evidence suggests that the extracellular matrix (ECM) in brain plays an important role in etiology of AD. Varied levels of ECM proteins have been detected in the brains of AD patients and animal models. Some ECM components, for example, collagen VI and laminin, are shown to interacted with amyloid‐beta (Aβ) peptides, involved in the aggregation of those peptides. Read more about this in the Minireview by F. Ye, K. Liu et al. on page 12101 ff.