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Frontispiece: Library Design Strategies To Accelerate Fragment‐Based Drug Discovery
Author(s) -
Troelsen Nikolaj S.,
Clausen Mads H.
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202085062
Subject(s) - fragment (logic) , drug discovery , combinatorial chemistry , chemistry , computer science , linkage (software) , mass spectrometry , computational biology , stereochemistry , nanotechnology , algorithm , materials science , biochemistry , chromatography , biology , gene
When doing a challenging puzzle , having colored pieces can make it significantly easier to solve compared to non‐colored pieces. Similarly, the use of augmented fragment libraries for fragment‐based drug discovery (FBDD) may significantly aid the development of a new drug compared to the use of standard fragment libraries. Such library strategies include the application of specialized fragments for NMR spectroscopy and X‐ray crystallography, covalent linkage for mass spectrometry, dynamic combinatorial chemistry, and optimized fragments. These approaches may accelerate drug discovery either by improving the speed or quality of fragment‐based screening or by enabling faster hit‐to‐lead chemistry for fragment elaboration. For more details see the Minireview by N. S. Troelsen and M. H. Clausen on page 11391 ff.