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Frontispiece: An Air‐ and Water‐Stable Hydrogen‐Bond‐Donor Catalyst for the Enantioselective Generation of Quaternary Carbon Stereocenters by Additions of Substituted Cyanoacetate Esters to Acetylenic Esters
Author(s) -
Luu Quang H.,
Gladysz John A.
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202084563
Subject(s) - stereocenter , enantioselective synthesis , catalysis , chemistry , hydrogen bond , organic chemistry , carbon fibers , molecule , materials science , composite number , composite material
The addition of substituted cyanoacetate esters to acetylenic esters (represented by two meteorites) is a powerful approach to installing quaternary carbon stereocenters. High enantioselectivities can be achieved using the enantiopure chiral cobalt(III) catalyst Δ‐[Co(( S , S )‐dpen) 3 ] 2Cl − B(C 6 F 5 ) 4 − ; there is no need to exclude air or water. The cobalt(III) trication can be visualized as a spaceship that uses NH hydrogen‐bond donor groups like laser guns to pull the components together. More information can be found in the Full Paper by Luu and Gladysz on page 10230 ff.