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Frontispiece: Transition Metal Promoted Cascade Heterocycle Synthesis through C−H Functionalization
Author(s) -
Baccalini Alessio,
Faita Giuseppe,
Zai Giuseppe,
Maiti Debabrata
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202084464
Subject(s) - cascade reaction , domino , surface modification , cascade , combinatorial chemistry , tandem , transition metal , chemistry , sequence (biology) , materials science , catalysis , organic chemistry , chromatography , composite material , biochemistry
Sequential, domino and tandem reactions could be defined as a sequence of synthetic transformations that occur one after the other, in the same reaction flask. This Review highlights recent advances on the transition‐metal‐mediated C−H activation as a trigger of cascade reactions for the synthesis of heterocycles. To shed some light on this research area at the intersection of two fields, focus was put on the reaction mechanism rather than on the type of metal or the chronological order of the reaction. The aim is to separate and highlight the true domino reactions initiated by C−H activation, compared to other examples of C−H functionalization for heterocycle synthesis. For more details see the Review by D. Maiti, G. Zanoni et al. on page 9749 ff.