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Frontispiece: Mechanochemical Synthesis of Short DNA Fragments
Author(s) -
Thorpe James D.,
O'Reilly Daniel,
Friščić Tomislav,
Damha Masad J.
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202084163
Subject(s) - phosphoramidite , dna , phosphonate , rna , mechanochemistry , dna synthesis , combinatorial chemistry , ball mill , chemistry , nanotechnology , materials science , oligonucleotide , biochemistry , composite material , gene
A “Mill & Shake” process to make DNA fragments : This study demonstrates that di‐ and trinucleotides can be assembled under ball‐milling conditions by multi‐step reactions, in a one‐pot fashion, and in the absence of bulk solvents. The process is fully compatible with H‐phosphonate and phosphoramidite chemistries, currently applied to oligo‐DNA and RNA synthesis. For more information, see the Communication by M. J. Damha et al. on page 8857 ff.