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Frontispiece: The ABC of Insulin: The Organic Chemistry of a Small Protein
Author(s) -
Østergaard Mads,
Mishra Narendra Kumar,
Jensen Knud J.
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202083862
Subject(s) - insulin , biopharmaceutical , chemistry , combinatorial chemistry , organic chemistry , medicine , endocrinology , biology , genetics
Insulin is a fascinating small protein that is accessible to synthetic organic chemistry. It is amenable to a wide range of chemical reactions, such as acylations, reductive alkylations, reduction, and binding of different metal ions, which can modify it properties. Insulin is also a very important biopharmaceutical and chemically modified insulin derivatives have provided diabetes patients with new treatment options. The approaches to chemical modification of insulin described here may serve as an inspiration for chemistry on other proteins. Read more in the Review by K. J. Jensen on page 8341 ff.