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Frontispiece: Exploring the Biocatalytic Potential of Fe/α‐Ketoglutarate‐Dependent Halogenases
Author(s) -
Voss Moritz,
Honda Malca Sumire,
Buller Rebecca
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202083361
Subject(s) - substrate (aquarium) , halogenation , enzyme , substrate specificity , chemistry , protein engineering , combinatorial chemistry , biochemical engineering , computer science , biochemistry , stereochemistry , engineering , organic chemistry , biology , ecology
Freestanding Fe/α‐ketoglutarate‐dependent halogenases are interesting development targets as they may serve as valuable tools for the synthesis of high‐value compounds. To date, a small number of indole alkaloid and amino acid halogenases have been identified and characterized. Initial enzyme engineering examples indicate that the accessible substrate range of these enzymes may be expanded whereas their throughout biophysical characterization continues to inform about the principles governing the halogenation mechanism. For more information see the Concept article by R. Buller et al. on page 7336 ff.