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Frontispiece: Ruthenium‐Induced Cyclization of Heteroatom‐Functionalized Alkynes: Progress, Challenges and Perspectives
Author(s) -
Chung LaiHon,
Yeung ChiFung,
Wong ChunYuen
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202082862
Subject(s) - alkyne , ruthenium , heteroatom , electrophile , chemistry , combinatorial chemistry , catalysis , organic chemistry , ring (chemistry)
Ruthenium catalysts for the synthesis of heterocycles : Metal‐induced cyclization of functionalized alkynes represents one of the most general approaches to prepare organic heterocycles. Although Ru II centers are well‐established to promote alkyne to vinylidene rearrangements and many Ru II ‐mediated alkyne cyclizations have been rationalized to be the results of post‐vinylidene transformations, recent discoveries indicate that Ru II centers can serve as electrophiles and induce alkyne cyclizations without vinylidene intermediacy. In their Minireview on page 6102 ff., C.‐Y. Wong et al. give an overview of the Ru II ‐induced cyclization of heteroatom‐functionalized alkynes in the last decade, with an emphasis on the discoveries and validations of the unconventional “non‐vinylidene‐involving” pathways.