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Frontispiece: Ligand Taxonomy for Bioinorganic Modeling of Dioxygen‐Activating Non‐Heme Iron Enzymes
Author(s) -
Park Hyunchang,
Lee Dongwhan
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202082761
Subject(s) - bioinorganic chemistry , chemistry , ligand (biochemistry) , heme , denticity , stereochemistry , combinatorial chemistry , enzyme , coordination complex , metal , biochemistry , organic chemistry , receptor
Enzymes have evolved over billions of years to meet specific functional demands. The extraordinary efficiency and selectivity of such biological catalysts continue to inspire the design and synthesis of their small‐molecule surrogates. In the relatively short history of synthetic bioinorganic chemistry, designer ligands have also been evolved from simple classical Werner‐type ligands. As an illustrative example that showcases the design thought process, in their Concept article on page 5916 ff., H. Park and D. Lee build “taxonomic trees” for the synthetic mimics of O 2 ‐activating non‐heme iron enzymes. Primary emphasis is placed on how the combination of ligand donor groups, denticity, and backbone topology collectively dictate the coordination chemistry of the metal center of immediate relevance to the oxidation/oxygenation reactivity.