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Frontispiece: Halogen Bonding Interactions of Polychlorinated Biphenyls and the Potential for Thyroid Disruption
Author(s) -
Marsan Eric S.,
Bayse Craig A.
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202082363
Subject(s) - microplastics , environmental chemistry , pollutant , thyroid , endocrine system , environmental science , chemistry , zoology , hormone , ecology , biology , endocrinology , biochemistry
Polychlorinated biphenyls (PCBs) are known endocrine disrupting pollutants found in microplastics. These persistent contaminants pose a threat to marine ecosystems and the human populations that depend on the sea for food. Density functional theory models provide support for a mechanism of toxicity through which halogen bonding of PCBs to selenoprotein deiodinases (DIO) block thyroid hormone activation. Art by Jordan Shackelford. For more information see the Full Paper by E. S. Marsan and C. A. Bayse on page 5200 ff.