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Frontispiece: Transition‐Metal‐Free Multiple Functionalization of Piperidines to 4‐Substituted and 3,4‐Disubstituted 2‐Piperidinones
Author(s) -
ChamorroArenas Delfino,
NolascoHernández Alejandro A.,
Fuentes Lilia,
Quintero Leticia,
SartilloPiscil Fernando
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202082163
Subject(s) - surface modification , transition metal , chemistry , chemical modification , cascade , combinatorial chemistry , organic chemistry , computational chemistry , polymer chemistry , catalysis , chromatography
The C−H functionalization of unreactive sp 3 carbon atoms under transition‐metal‐free conditions contribute, not only to the invention of novel methodologies and synthetic strategies, but also to the development of greener and more sustainable organic chemical processes. With this aim in mind, the direct functionalization of simple piperidines into substituted 2‐piperidones and relevant pharmaceutical alkaloids was achieved thought the development of two transition‐metal‐free cascade reactions. For more information see the Communication by F. Sartillo‐Piscil et al. on page 4671 ff.