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Frontispiece: Designing Molecular Spanners to Throw in the Protein Networks
Author(s) -
Serapian Stefano A.,
Colombo Giorgio
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202082162
Subject(s) - computational biology , computer science , block (permutation group theory) , protein–protein interaction , biology , microbiology and biotechnology , mathematics , combinatorics
Most aspects of cellular life are regulated through specific protein–protein interactions. Classical methods to investigate or manipulate such interactions are based on the shutdown through orthosteric ligands that block the active sites. Alternative methods to modulate protein functions and protein–protein interactions based on the view that a protein is a dynamic entity are summarized in the Minireview by G. Colombo and S. A. Serapian on page 4656 ff.