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Frontispiece: Role of Gold in Inflammation and Tristetraprolin Activity
Author(s) -
Ok Kiwon,
Li Wenjing,
Neu Heather M.,
Batelu Sharon,
Stemmler Timothy L.,
Kane Maureen A.,
Michel Sarah L. J.
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202080763
Subject(s) - tristetraprolin , zinc finger , reactivity (psychology) , chemistry , zinc , rna , rna binding protein , biochemistry , medicine , organic chemistry , alternative medicine , pathology , transcription factor , gene
Native nano ESI‐mass spectrometry can be applied to track the formation of “Gold Fingers” formed when Au III ‐terpy reacts with the non‐classical zinc finger protein tristetraprolin. This powerful MS technique can also be utilized to probe reactivity of RNA bound zinc fingers, and it is reported that RNA has a protective effect towards Gold Finger reactivity with tristetraprolin. For more details, see the Full Paper by S. L. J. Michel and co‐workers on page 1535 ff.