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Frontispiece: Unlocking the Drug Potential of the Bryostatin Family: Recent Advances in Product Synthesis and Biomedical Applications
Author(s) -
Wu Rongzhen,
Chen Hongyu,
Chang Ninghui,
Xu Yuzhi,
Jiao Jiao,
Zhang Hailong
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202080661
Subject(s) - natural product , drug discovery , zhàng , computational biology , biology , chemistry , stereochemistry , bioinformatics , history , archaeology , china
Bryostatins, a class of naturally occurring macrocyclic lactones with eleven chiral centers, which were isolated from marine invertebrates, turned out as promising candidates for medicinal applications, including AIDS, Alzheimer's disease, and cancer. The ongoing work towards the total synthesis of bryostatins and structural analogues (bryologs) as well as the biomedical application of these compounds is summarized in the Review by J. Jiao, H. Zhang et al. on page 1166 ff.