Premium
Frontispiece: Evidence for a Proton‐Coupled Electron Transfer Mechanism in a Biomimetic System for Monoamine Oxidase B Catalysis
Author(s) -
Nakamura Akiko,
Latif Marwa Abdel,
Deck Paul A.,
Castagnoli Neal,
Tanko James M.
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202080463
Subject(s) - electron transfer , proton coupled electron transfer , monoamine oxidase , catalysis , chemistry , proton , monoamine oxidase b , mechanism (biology) , photochemistry , enzyme , organic chemistry , physics , quantum mechanics
The image shows that single electron transfer is “back on the menu” as a possible mechanism for catalysis by monoamine oxidase B (MAO‐B). By using a chemical model for MAO‐B, a compelling evidence that the initial chemical step of the oxidation of certain tertiary amines involves proton‐coupled electron transfer (PCET) is provided. Molecular oxygen is found to play a key, hitherto unrecognized role in the early steps of the catalysis. The structural/electronic properties of the substrates that provide entry into the electron transfer pathway have been identified and are presented in the Full Paper by J. M. Tanko et al. on page 823 ff.