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Frontispiece: More than Proton Detection—New Avenues for NMR Spectroscopy of RNA
Author(s) -
Schnieders Robbin,
Keyhani Sara,
Schwalbe Harald,
Fürtig Boris
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202080165
Subject(s) - nuclear magnetic resonance spectroscopy , rna , spectroscopy , chemistry , characterization (materials science) , nuclear magnetic resonance spectroscopy of nucleic acids , proton , fluorine 19 nmr , transverse relaxation optimized spectroscopy , nanotechnology , materials science , physics , biochemistry , stereochemistry , gene , nuclear physics , quantum mechanics
Since the development of multidimensional NMR spectroscopy and the availability of isotope labeled RNAs, NMR spectroscopy has contributed more than 40 % of all RNA structures in databases. Considerable challenges, however, remain for the structure determination particularly of large RNAs and their complexes by biomolecular NMR spectroscopy. In their Minireview on page 102 ff., H. Schwalbe and B. Fürtig et al. describe newly established carbon‐ and nitrogen‐detection NMR experiments that allow characterization of RNA structure and dynamics where traditional proton‐based techniques fail.