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Frontispiece: Photochemical Reactions in the Synthesis of Protein–Drug Conjugates
Author(s) -
Holland Jason P.,
Gut Melanie,
Klingler Simon,
Fay Rachael,
Guillou Amaury
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202080162
Subject(s) - bioconjugation , chemistry , electrophile , reagent , combinatorial chemistry , radical , chemical biology , ligand (biochemistry) , photochemistry , organic chemistry , biochemistry , receptor , catalysis
This article introduces some of the principles and objectives of combining photochemistry with bioconjugation chemistry. Photoradiosynthesis which is defined as using photochemically activated reagents for protein ligation of radiolabelled antibodies for use in molecular imaging, is introduced as a working example. Notably, the goal of producing functionalised proteins in the absence of pre‐association (noncovalent ligand–protein binding) stipulates requirements that are distinct from the more regular use of photoactive groups in photoaffinity labelling. As representative for the chemical and mechanistic scope of photochemical reactions that harbour potential for bimolecular protein functionalisation, the chemistry of thirteen different classes of photoactivatable reagents, which harbour potential for bimolecular protein functionalisation and which react through the formation of intermediate carbenes, electrophiles, dienes or radicals, is assessed. For more details see the Concept by J. P. Holland et al. on page 33 ff.