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One‐Pot Dual C−C Coupling Reaction via Site Selective Cascade Formation by Pd II ‐Cryptate of an Amino‐Ether Heteroditopic Macrobicycle
Author(s) -
Sarkar Sayan,
Sarkar Piyali,
Munshi Sandip,
Ghosh Pradyut
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202005397
Subject(s) - chemistry , aryl , palladium , iodide , cascade , ether , catalysis , selectivity , coupling reaction , cascade reaction , coupling (piping) , combinatorial chemistry , medicinal chemistry , photochemistry , polymer chemistry , organic chemistry , materials science , alkyl , chromatography , metallurgy
Selectivity of aryl iodo over ethynyl iodo toward the Suzuki cross coupling reaction is explored by utilizing a palladium complex of amino‐ether heteroditopic macrobicycle. Subsequently, unreacted ethynyl iodide undergoes homocoupling reaction in the same catalytic atmosphere, thereby representing a cascade dual C−C coupling reaction. Furthermore, this approach is extended for novel one‐pot synthesis of unsymmetrical 1,3‐diynes.