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Double‐Network Heparin Dynamic Hydrogels: Dynagels as Anti‐bacterial 3D Cell Culture Scaffolds
Author(s) -
Cui Han,
Wang Qimeng,
Zhang Ye,
Barboiu Mihail,
Zhang Yan,
Chen Jinghua
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202005376
Subject(s) - self healing hydrogels , biocompatibility , heparin , 3d cell culture , imine , cell encapsulation , chemistry , bacterial cellulose , chemical engineering , materials science , polymer chemistry , cell , biochemistry , organic chemistry , cellulose , engineering , catalysis
Double cross‐linked dynamic hydrogels, dynagels, have been prepared through reversible imine bonds and supramolecular interactions, which showed good pH responsiveness, injectability, self‐healing property and biocompatibility. With the further encapsulation of heparin, the obtained hydrogels exhibited good anti‐bacterial activity and promotion effects for 3D cell culture.