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Approaches to the Synthesis of Perfluoroalkyl‐Modified Carbohydrates and Derivatives: Thiosugars, Iminosugars, and Tetrahydro(thio)pyrans
Author(s) -
Uhrig María Laura,
Mora Flores Erwin W.,
Postigo Al
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202005229
Subject(s) - chemistry , glycosyltransferase , supramolecular chemistry , combinatorial chemistry , thio , organic chemistry , enzyme , molecule
Fluoroalkyl‐substituted carbohydrates play relevant roles in diverse areas such as supramolecular chemistry, glycoconjugation, liquid crystals, and surfactants, with direct applications as wetting, antifreeze, and coating agents. In light of these promising applications, new methodologies for the late‐stage incorporation of fluoroalkyl R F groups into carbohydrates and derivatives are herein presented as they are relevant to the synthetic carbohydrate community. Previously reviewed protocols for the installation of R F groups onto carbohydrates and derivatives will be succinctly summarized in the light of the new achievements. Fluoroalkyl‐substituted iminosugars, on the other hand, are also interesting glycomimetic derivatives with prominent roles as glycosidases and glycosyltransferases inhibitors, as has recently been demonstrated. Also, they positively contribute to the study of sugar–protein interactions and enzyme mechanisms. New advances in the syntheses of fluoroalkyl‐substituted iminosugars will also be presented here.