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Catalytic Asymmetric Addition of Diorganozinc Reagents to Pyrazole‐4,5‐Diones and Indoline‐2,3‐Diones
Author(s) -
Wang RongHui,
Li YaLing,
He HongJiao,
Xiao YouCai,
Chen FenEr
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202005081
Subject(s) - indoline , morpholine , enantioselective synthesis , chemistry , catalysis , reagent , chiral ligand , functional group , alcohol , pyrazole , organic chemistry , combinatorial chemistry , polymer
The catalytic enantioselective diorganozinc additions to cyclic diketones including pyrazolin‐4,5‐diones and isatins have been developed. In the presence of morpholine‐containing chiral amino alcohol ligand, the corresponding chiral cyclic tertiary alcohols were produced in good to excellent yields (up to 97 %) and enantioselectivities (up to 95 % ee ). The notable feature of this protocol includes its mild reaction conditions, Lewis acid additives free and broad functional group tolerance.