Premium
Synthesis of Ajoene Analogues by Novel Synthetic Strategies
Author(s) -
Yamamoto Raynbird Marina,
Khokhar Shaista S.,
Neef Daniel,
Evans Gareth J. S.,
Wirth Thomas
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202005023
Subject(s) - sulfoxide , alkene , chemistry , combinatorial chemistry , sulfone , stereochemistry , organic chemistry , catalysis
Abstract Ajoene is a compound found in garlic extracts exhibiting a large range of biological activity. Novel ajoene analogues have been prepared in the search of compounds with superior bioactivity. Modifications include the alteration of the sulfoxide, the central alkene and the terminal allyl groups.