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Cover Feature: Simple Synthesis of a Heterocyclophane Exhibiting Anti‐c‐Met Activity by Acting as a Hatch Blocking Access to the Active Site (Chem. Eur. J. 5/2021)
Author(s) -
Takimoto Tatsuya,
Sasaki Hideaki,
Tsue Hirohito,
Takahashi Hiroki,
MacKerell Alexander D.,
Nakamura Ayumi,
Nakano Katsuya,
Okazaki Eori,
Betsuyaku Tatsuki,
Tachibana Ryosuke,
Hioki Kazuhito,
Yoluk Ozge,
Jo Sunhwan
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202004973
Subject(s) - cyclophane , cover (algebra) , simple (philosophy) , blocking (statistics) , feature (linguistics) , combinatorial chemistry , chemistry , computer science , organic chemistry , engineering , philosophy , mechanical engineering , computer network , linguistics , epistemology , molecule
Rapidly synthesis of suitable drug candidates using both a simple cyclophane synthesis and the fragmap method of SILCS in computational chemistry is reported in this work. The cover image depicts cyclophane synthesis using a waffle‐making device so that it is easy to imagine that cyclophane derivatives can be quickly synthesized by heat. More information can be found in the Full Paper by H. Sasaki et al. on page 1648.