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Recent Advances in Enantioselective Desymmetrizations of Prochiral Oxetanes
Author(s) -
Sandvoß Alexander,
Wahl Johannes M.
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202004923
Subject(s) - enantioselective synthesis , desymmetrization , context (archaeology) , chemistry , organic chemistry , combinatorial chemistry , catalysis , biology , paleontology
Strain relief of oxetanes offers a plethora of opportunities for the synthesis of chiral alcohols and ethers. In this context, enantioselective desymmetrization has been identified as a powerful tool to construct molecular complexity and this has led to the development of elegant strategies on the basis of transition metal, Lewis acid, and Brønsted acid catalysis. This review highlights recent examples that harness the inherent reactivity of prochiral oxetanes and offers an outlook on the immense possibilities for synthetic application.